Lentiviral human ERCC5 sgRNA gene knockout kit

Human ERCC5

Gene symbol: ERCC5
Synonyms: COFS3 ERCC5-201 ERCM2 UVDR XPG XPGC
Species: HUMAN
Gene ID: 2073
Summary: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000123:8:8