Lentiviral human ERCC2 sgRNA gene knockout kit

Human ERCC2

Gene symbol: ERCC2
Synonyms: COFS2 EM9 TFIIH TTD TTD1 XPD
Species: HUMAN
Gene ID: 2068
Summary: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000400:8:8 NM_001130867:7:7