Lentiviral human ATF6B sgRNA gene knockout kit

Human ATF6B

Gene symbol: ATF6B
Synonyms: CREB-RP CREBL1 G13
Species: HUMAN
Gene ID: 1388
Summary: The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_004381:7:7