Lentiviral human ATF4 sgRNA gene knockout kit

Human ATF4

Gene symbol: ATF4
Synonyms: CREB-2 CREB2 TAXREB67 TXREB
Species: HUMAN
Gene ID: 468
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001675:1:1 NM_182810:2:1