Lentiviral human APP sgRNA gene knockout kit

Human APP

Gene symbol: APP
Synonyms: AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 preA4
Species: HUMAN
Gene ID: 351
Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000484:5:5 NM_201413:5:5 NM_201414:5:5 NM_001136016:5:5 NM_001136129:4:4 NM_001136130:4:4 NM_001136131:5:4 NM_001204301:5:5 NM_001204302:5:5 NM_001204303:5:5