Lentiviral human ANK2 sgRNA gene knockout kit

Human ANK2

Gene symbol: ANK2
Synonyms: ANK-2 brank-2 LQT4
Species: HUMAN
Gene ID: 287
Summary: This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001148:27:27 NM_001354225:28:28 NM_001354228:27:27 NM_001354230:29:29 NM_001354231:28:28 NM_001354232:28:28 NM_001354235:28:28 NM_001354236:28:28 NM_001354237:29:29 NM_001354239:30:29 NM_001354240:27:27 NM_001354241:28:28 NM_001354242:28:28 NM_001354243:28:27 NM_001354244:29:28 NM_001354245:27:27 NM_001354246:28:28 NM_001354249:27:26 NM_001354252:30:29 NM_001354253:28:27 NM_001354254:29:28 NM_001354255:28:27 NM_001354256:29:28 NM_001354257:27:26 NM_001354258:27:27 NM_001354260:26:25 NM_001354261:28:27 NM_001354262:28:27 NM_001354264:27:26 NM_001354265:28:28 NM_001354266:27:26 NM_001354267:27:26 NM_001354268:26:26 NM_001354269:26:26 NM_001354270:28:27 NM_001354271:26:25 NM_001354272:30:29 NM_001354273:26:26 NM_001354274:27:26 NM_001354275:28:27 NM_001354276:27:26 NM_001354277:25:24 NM_001354278:7:7 NM_001354279:8:8 NM_001354280:7:7 NM_001354281:7:7 NM_001354282:8:8 NM_001127493:29:28 NM_020977:27:27