Lentiviral human ADAM15 sgRNA gene knockout kit

Human ADAM15

Gene symbol: ADAM15
Synonyms: MDC15
Species: HUMAN
Gene ID: 8751
Summary: The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_207191:9:9 NM_207194:9:9 NM_207195:9:9 NM_207196:9:9 NM_207197:9:9 NM_001261464:9:9 NM_001261465:9:9 NM_001261466:9:9 NM_003815:9:9