Lentiviral human ADAM11 sgRNA gene knockout kit

Human ADAM11

Gene symbol: ADAM11
Synonyms: MDC
Species: HUMAN
Gene ID: 4185
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_002390:11:11 NM_001318933:11:5