Lentiviral human ABCD4 sgRNA gene knockout kit

Human ABCD4

Gene symbol: ABCD4
Synonyms: ABC41 EST352188 MAHCJ P70R P79R PMP69 PXMP1L
Species: HUMAN
Gene ID: 5826
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in several protein-coding and non-protein-coding variants. [provided by RefSeq, Jul 2017].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_005050:10:10 NM_020324:9:6 NM_020325:10:10 NM_001353591:9:9 NM_001353592:9:9 NM_001353593:9:8 NM_001353594:8:7 NM_001353595:10:7 NM_001353596:9:7 NM_001353597:8:6 NM_001353598:8:6 NM_001353599:9:6 NM_001353600:9:6 NM_001353601:8:6 NM_001353602:9:3 NM_001353603:8:3 NM_001353604:7:3 NM_001353605:9:3 NM_001353606:8:3 NM_001353607:7:3 NM_001353608:8:3 NM_001353609:9:3 NM_001353610:9:3