Lentiviral human ABCC8 sgRNA gene knockout kit

Human ABCC8

Gene symbol: ABCC8
Synonyms: ABC36 HHF1 HI HRINS MRP8 PHHI SUR SUR1 SUR1delta2 TNDM2
Species: HUMAN
Gene ID: 6833
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001287174:4:4 NM_000352:4:4 NM_001351295:4:4 NM_001351296:4:4 NM_001351297:4:4