Lentiviral BRCC3 sgRNA CRISPR/Cas9

BRCC3 (BRCA1/BRCA2-Containing Complex Subunit 3) is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.

This lentivirus expresses human BRCC3 sgRNA under the control of the U6 promoter, Cas9 nuclease and puromycin under the control of the EF1a promoter.

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