Lentiviral COPS2 sgRNA CRISPR/Cas9

COPS2 (COP9 Signalosome Subunit 2) is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.

This lentivirus expresses human COPS2 sgRNA under the control of the U6 promoter, Cas9 nuclease and puromycin under the control of the EF1a promoter.

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