LDN 57444 , 98% by HPLC

LDN 57444 , 98% by HPLC

Catalog Number:
P004516992LIF
Mfr. No.:
PEPTIDE-PI-001
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  • Size:
    10mg
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      • Overview

        • Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor.
          LDN 57444 is an inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity with a Ki of 0.4 M. UCH-L1 is a deubiquitinating enzyme that is abundantly expressed in the brain, and its activity is required for normal synaptic function. Inhibition by LDN 57444 causes cell death through the apoptosis pathway, increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity.

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      • Properties
        • Categories
          Small Molecules
          Molecular Formula
          C17H11Cl3N2O3
          Molecular Weight
          397.64
          Appearance
          Freeze dried solid
          Purity
          98% by HPLC
          Solubility
          Soluble to 50 mM in DMSO
          Other Properties
          Sequence: 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime),5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)
          Storage
          Store desiccated, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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