Application Description
LacBuster™-S can be applied for sterility testing of β-lactam antibiotics by membrane filtration according to US and European Pharmacopeia methods. It can be easily incorporated into existing standard operating procedures by addition of the reconstituted sterile-filtered enzyme solution to all buffers and media. To validate complete inactivation of the β-lactam a challenge test (using less than 100 colony-forming units of Staphylococcus aureus ATCC 6538 or Bacillus subtilis ATCC 6633) with an appropriate quantity of enzyme has to be performed under the customer-specific settings. Please refer to our application specialists for further advice. Further applications include environmental monitoring of manufacturing areas and sterility testing of blood cultures.