Name: KU 55933
Price: 212.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    KU-55933 is a specific inhibitor of ATM kinase with IC50 value of 13 nM [1].
    ATM can stimulate Ser473 phosphorylation of Akt and mediate its full activation in response to insulin. As an ATM inhibitor, KU-55933 significantly inhibited the increase of phospho-Akt at Ser473 in MDA-MB-453 and PC-3 cells treated with insulin and IGF-I following serum starvation. In the MTT assay, KU-55933 treatment suppressed cell proliferation by about 50% at concentration of 10 μM in MDA-MB-453 and PC-3 cells. In a panel of cell lines that have varied Akt activities, KU-55933 treatment caused cell proliferation inhibition correlated with the Akt phosphorylation. KU-55933 was also found to induce G1 cell cycle arrest through down-regulating the cyclin D1 level in MDA-MB-453 and PC-3 cells [2].
    
    [1] Hickson I, Zhao Y, Richardson C J, et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer research, 2004, 64(24): 9152-9159.
    [2] Li Y, Yang D Q. The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt. Molecular cancer therapeutics, 2010, 9(1): 113-125.
- Properties
  - Alternative Name
    
    2-morpholin-4-yl-6-thianthren-1-ylpyran-4-one
    
    CAS Number
    
    587871-26-9
    
    Molecular Formula
    
    C21H17NO3S2
    
    Molecular Weight
    
    395.49
    
    Appearance
    
    A solid
    
    Purity
    
    99.89%
    
    Solubility
    
    ≥41.67 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Desiccate at -20°C
    
    * For Research Use Only
- Reference
  - 1. Karin Broennimann, Inna Ricardo-Lax, et al. "RNR-R2 Upregulation by a Short Non-Coding Viral Transcript." Biomolecules. 2021 Dec 3;11(12):1822. PMID:34944466
    2. Zheng K, Ma J, et al. "Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3." Mol Nutr Food Res. 2020;e1901231. PMID:32476238
    3. Sarkar R, Patra U, et al. "Rotavirus activates a noncanonical ATM-Chk2 branch of DNA damage response during infection to positively regulate viroplasm dynamics." Cell Microbiol. 2019 Dec 17:e13149. PMID:31845505
    4. Inna Ricardo-Lax, Karin Broennimann, et al. "A short HBV RNA region induces RNR-R2 expression in non-cycling cells and in primary human hepatocytes." bioRxiv. 2018 October 31.

KU 55933

KU 55933

Background

We Also Recommend

ApexPrep DNA Plasmid Miniprep Column Only

ApexPrep DNA Plasmid Miniprep Kit