Name: K-Ras(G12C) inhibitor 6
Price: 277.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    K-Ras (G12C) inhibitor 6 is an allosterical inhibitor of oncogenic mutation K-Ras G12C [1].K-Ras (G12C) inhibitor 6 is a cysteine-reactive small molecule. It irreversibly binds to the G12C mutantion of GTPase K-Ras but not the wild-type K-Ras with the relative potency value of 4.2. The binding pocket of K-Ras for K-Ras (G12C) inhibitor 6 is a new allosteric pocket, S-IIP. Binding of this pocket results in a change of the relative nucleotide affinity of Ras to favour GDP over GTP, leading to an accumulation of inactive Ras. Since the mutation of K-Ras is quite common in human cancers, the inhibitor of K-Ras G12C should exert suppression activities in tumor cells. It has been reported that, some of the K-Ras G12C inhibitors are indeed effective to decrease cell viability and increase apoptosis in lung cancer cell lines [1].
    
    [1] Ostrem J M, Peters U, Sos M L, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 2013, 503(7477): 548-551.
- Properties
  - CAS Number
    
    2060530-16-5
    
    Molecular Formula
    
    C17H22Cl2N2O3S
    
    Molecular Weight
    
    405.34
    
    Appearance
    
    A solid
    
    Purity
    
    98.10%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥20.25 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

K-Ras(G12C) inhibitor 6

K-Ras(G12C) inhibitor 6

Background

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