Name: IWR-1-endo
Price: 188.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    IWR-1-endo is a small molecule inhibitor of Wnt Response with IC50 value of 180nM [1].
    IWR-1-endo is a small molecule antagonists of the Wnt/β-catenin pathway screened out from a diverse synthetic chemical library. It acts as an inhibitor of Wnt response. IWR-1-endo can inhibit the activity of Wnt1, 2 and 3. In cultured cells, IWR-1-endo inhibits Wnt-induced β-catenin accumulation which is a downstream event of Lrp6 and Dvl2. It is proved that IWR-1-endo promote β-catenin destruction through promoting stability of Axin-scaffolded destruction complexes in the DLD-1 colorectal cancer (CRC) cell line. IWR-1-endo is also shown to inhibit tailfin regeneration and epithelial stem cell self-renewal in zebrafish. These two processes are both dependent on Wnt/β-catenin signaling. Furthermore, IWR-1-endo can block aberrant cell growth supported by hyperactivation of Wnt/β-catenin resulting from Apc loss [1].
    
    [1] Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.
- Properties
  - Alternative Name
    
    4-((3aR,4S,7R,7aS)-1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-(quinolin-8-yl)benzamide
    
    CAS Number
    
    1127442-82-3
    
    Molecular Formula
    
    C25H19N3O3
    
    Molecular Weight
    
    409.44
    
    Appearance
    
    A solid
    
    Purity
    
    98.44%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥20.45 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Qi Zhu, Dinghui Wang, et al. "Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ." J Biol Chem. 2022 Jul 31;102309. PMID: 35921899
    2. Yang H, Li G, et al. "Secreted frizzled-related protein 2 promotes the osteo/odontogenic differentiation and paracrine potentials of stem cells from apical papilla under inflammation and hypoxia conditions." Cell Prolif. 2019 Sep 30:e12694. PMID: 31568642
    3. Suknuntha K, Tao L, et al. "Optimization of Synthetic mRNA for Highly Efficient Translation and its Application in the Generation of Endothelial and Hematopoietic Cells from Human and Primate Pluripotent Stem Cells." Stem Cell Rev. 2018 Mar 8. PMID: 29520567

IWR-1-endo

IWR-1-endo

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