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Overview
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Background
BAY 11-7085 is a soluble inhibitor of NK-κB activation [1].
BAY 11-7085 has been reported to inhibit cell proliferation and induce cell apoptosis in a variety of cells. In addition, BAY 11-7085 has been revealed to inhibit DNA synthesis of ECSCs and induce the G0/G1 phase cell cycle arrest. Moreover, BAY 11-7085 has shown to induce cell apoptosis by inhibiting anti-apoptotic proteins. After treatment with BAY 11-7085, down-regulations of the B-cell lymphoma/leukemia-2 (Bcl-2) and Bcl-XL expressions with simultaneous activations of caspase-3, caspase-8, and caspase-9 were observed in ECSCs. [1].[1]Nasu K1, Nishida M, Ueda T, Yuge A, Takai N, Narahara H. Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E16-23
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