Name: Irgasan (Triclosan)
Price: 149.00 USD

- Overview
  - Irgasan (Triclosan) is a broad spectrum antibacterial agent that inhibits bacterial fatty acid synthesis. Irgasan is slightly soluble in water and freely soluble in ethanol and methanol.
    
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    Background
    
    Irgasan demonstrates a bacteriostatic effect by binding to the enoyl-acyl carrier protein reductase (enoyl-ACP), an enzyme involved in fatty acid synthesis. After forming a complex, nicotinamide adenine dinucleotide (NAD) binds and prevents enoyl-ACP from participating in the fatty acid synthesis cycle which inhibits bacterial cell growth. Triclosan permeabilizes the bacterial envelope.
- Properties
  - CAS Number
    
    3380-34-5
    
    Molecular Formula
    
    C12H7Cl3O2
    
    Molecular Weight
    
    289.54
    
    Appearance
    
    White powder
    
    Solubility
    
    Basic solution: Soluble
    Diethyl ether: Soluble
    Ethanol: Soluble
    Methanol: Soluble
    Water: Slightly soluble
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤0.1%
    Assay: (Dried Basis): 97.0-103.0%
    Melting Point: 56-60 °C
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Irgasan is active against Gram-negative bacteria, Gram-positive bacteria, and fungi
    
    Microbiology Applications: Irgasan is used as a media supplement in Pseudomonas and Yersinia isolation media.
    During the 1990s, bacterial isolates with reduced susceptibility to Irgasan were produced by repeated exposure to sublethal concentrations. Since 2000, a number of studies have verified resistance among dermal, intestinal, and environmental microorganisms (Yazdankhah, 2006). Resistance in E. coli is acquired through a missense mutation in the fabl gene (Heath et al, 2010).
    
    Eukaryotic Cell Culture Applications: A widely used model for proliferative epidermis in tissue engineering are the HaCa T keratinocytes. The influence of Irgasan on the cell growth, viability, and proliferation of these keratinocytes was reviewed, since the formation of biofilms pose a serious difficulty in tissue replacement. Collagen-cell-attachment properties on the atelocollagen matrix were not affected by this biocide. Thus, sample type could serve as ‘antimicrobial substrates’, and play a role in the design of novel antimicrobial biomaterials suitable for tissue engineering. (Lopez-Garcia J et al, 2014).