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Herbimycin A

Herbimycin A

Catalog Number:
CR04341424TOK
Mfr. No.:
TOK-H002
Price:
$435
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      • Overview

        • Herbimcyin is a sparingly soluble benzoquinone anti-tumor agent which interacts with the stress-induced chaperone protein Hsp90 (heat shock protein 90).

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          Background

          Herbimycin A binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response.

      • Properties
        • CAS Number
          70563-58-5
          Molecular Formula
          C30H42N2O9
          Molecular Weight
          574.66
          Appearance
          Yellow powder
          Solubility
          DMSO: Soluble
          Other Properties
          Source: Streptomyces hygroscopicus
          Purity Level: (HPLC): ≥95.0%
          Storage
          -20°C

          * For research use only

      • Applications
        • Application Description
          Cancer Applications: In normal cells, Hsp90 stabilizes and folds proteins, however, in tumor cells, Hsp90 activity helps stabilize mutated growth factor and signal proteins which facilitate tumor growth. To prevent this complication, Herbimycin A binds to and inactivates Hsp90 in cancerous cells leading to degradation of cancer cell proteins.
    Datasheet
    MSDS

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