Introducing highly-defined, consistent and reliable human muscle cells for research, disease modelling and high throughput screening across areas such as muscle, neuromuscular, and associated metabolic disorders. ioSkeletal Myocytes have been reprogrammed from human induced pluripotent stem cells (iPSCs) using our precise reprogramming technology: opti-ox™¹.
The technology allows for human pluripotent stem cells, within days, to convert into skeletal myocytes, providing a high-quality, easy to use, cellular model.
Skeletal myocytes demonstrate robust expression of components of the contractile apparatus and form striated, multinucleated, myocytes by Day 10 post revival, that contract in response to acetylcholine.
Unprecedented batch-to-batch consistency allows for their use in demanding screening applications where small changes need to be detected against background noise.
Batch to batch reproducibility and homogeneity create a stable human model for the study of muscle, neuromuscular, and associated metabolic disorders.
Form striated, multinucleated, myocytes by Day 10 post revival, that contract in response to acetylcholine.
Industrial scale quantities at a price point that allows the cells to be used from research to screening scale.
■ Ease of Use
Cells arrive programmed to rapidly mature upon revival. One medium required in a two-step protocol.
Please contact us at for specific academic pricing.
TypeHuman-induced skeletal myocytesStorageUpon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments
* These cells are for research use only
Application Description– Muscle, neuromuscular and metabolic research
– Amenable to high throughput screening
– Contractility assays
– 3D cocultures
– Single cell CRISPR Screening
Zhou, L., Wolfes, A. C., Li, Y., Chan, D. C. W., Ko, H., Szele, F. G., Bayley, H., Lipid‐Bilayer‐Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions. Adv. Mater. 2020, 32, 2002183.
Pawlowski, Matthias et al. Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes. Stem Cell Reports, Volume 8, Issue 4, 803 - 812
We Also Recommend