ioGlutamatergic Neurons

ioGlutamatergic Neurons have been reprogrammed from human induced pluripotent stem cells (iPSC) using our precise reprogramming technology: opti-ox™¹ (optimized inducible overexpression). Human stem cells, within days, convert into consistent, mature, functional glutamatergic neurons providing a high quality human model for the study of neurological activity and disease.
ioGlutamatergic Neurons consist mainly of glutamatergic neurons (>80%) characterised by the expression of the glutamate transporter genes VGLUT1 and VGLUT2. The minor remaining fraction of the neuronal population express marker genes of cholinergic neurons. A bulk RNA-seq analysis shows that ioGlutamatergic Neurons have a rostral CNS identity and express the classical cortical marker genes FOXG1 and TBR1.
Ready-to-culture cells are suitable as models for research in cell-type specific biology, target validation and drug screening in pharmaceutical R&D, and toxicology testing.

■ Consistency
Batch to batch reproducibility and homogeneity create a stable human model for excitatory neuronal activity and disease.
■ Speed
Ready for experimentation as early as 2 days post revival and form functional neuronal networks at 17 days.
■ Scalability
Industrial scale quantities at a price point that allows the cells to be used from research to screening scale.
■ Ease of Use
Cells arrive programmed to rapidly mature upon revival. One medium required in a two-step protocol.

Please contact us at for specific academic pricing.