ioGlutamatergic Neurons

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      • Overview
        • ioGlutamatergic Neurons have been reprogrammed from human induced pluripotent stem cells (iPSC) using our precise reprogramming technology: opti-ox™¹ (optimized inducible overexpression). Human stem cells, within days, convert into consistent, mature, functional glutamatergic neurons providing a high quality human model for the study of neurological activity and disease.
          ioGlutamatergic Neurons consist mainly of glutamatergic neurons (>80%) characterised by the expression of the glutamate transporter genes VGLUT1 and VGLUT2. The minor remaining fraction of the neuronal population express marker genes of cholinergic neurons. A bulk RNA-seq analysis shows that ioGlutamatergic Neurons have a rostral CNS identity and express the classical cortical marker genes FOXG1 and TBR1.
          Ready-to-culture cells are suitable as models for research in cell-type specific biology, target validation and drug screening in pharmaceutical R&D, and toxicology testing.

          ■ Consistency
          Batch to batch reproducibility and homogeneity create a stable human model for excitatory neuronal activity and disease.
          ■ Speed
          Ready for experimentation as early as 2 days post revival and form functional neuronal networks at 17 days.
          ■ Scalability
          Industrial scale quantities at a price point that allows the cells to be used from research to screening scale.
          ■ Ease of Use
          Cells arrive programmed to rapidly mature upon revival. One medium required in a two-step protocol.

          Please contact us at  for specific academic pricing.

      • Properties
        • Type
          Human-induced glutamatergic neurons
          Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments

          * These cells are for research use only 

      • Applications
        • Application Description
          – Academic research
          – Drug development
          – Neurotoxicology
          – High-throughput screening
          – Single cell CRISPR Screening
          – 3D bioprinting
      • Reference

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