β-Interleukin I (163-171), human

- Overview
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    Background
    
    β-Interleukin I (163-171), human(C39H64N12O19), a peptide with the sequence Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys, MW= 1005. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). Interleukin 1 alpha and interleukin 1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.
    Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
    
    1. Contassot E, Beer HD, French LE (2012). "Interleukin-1, inflammasomes, autoinflammation and the skin". Swiss Med Wkly 142: w13590
    2. Matzinger P (2012). "The evolution of the danget theory. Interview by Lauren Constable, Commissioning Editor". Expert Rev Clin Immunol 8 (4): 311-7.
    3. Sahoo M, Ceballos-Olvera I, del Barrio L, Re F (2011). "Role of the inflammasome, IL-1β, and IL-18 inbacterial infections". ScientificWorldJournal 11: 2037-50.
- Properties
  - Categories
    
    T cell activator
    
    Alternative Name
    
    H2N-Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH; β-Interleukin I (163-171), human
    
    CAS Number
    
    106021-96-9
    
    Molecular Formula
    
    C39H64N12O19
    
    Molecular Weight
    
    1004.99
    
    Appearance
    
    A solid
    
    Purity
    
    99.58%
    
    Solubility
    
    insoluble in EtOH; ≥100.4 mg/mL in DMSO; ≥24.75 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C)C(C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)O)N
    
    * For Research Use Only