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Overview
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ING1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids (1-279 a.a) and having a molecular mass of 34.3kDa. ING1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Inhibitor of Growth Family Member 1, also known as ING1 is a tumorsuppressor protein which is able to induce cell growth arrest and apoptosis. ING1is a nuclear protein which physically act together with the tumor suppressorprotein TP53 and is a component of the p53 signaling pathway. In addition, Reducedexpression and rearrangement of ING1 have been identified in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoformshave been described for ING1.
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Overview