Name: Indomethacin heptyl ester
Price: 290.00 USD

- Overview
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    Background
    
    Indomethacin heptyl ester is a potent and selective COX-2 inhibitor with IC50 value of 0.04 μM [1]. The key step in thromboxane and prostaglandin biosynthesis involves the conversion of arachidonic acid to prostaglandin H2 (PGH2), a reaction catalyzed by the cyclooxygenase (COX) and peroxidase activities of prostaglandin endoperoxide synthase or cyclooxygenase. COX is composed of COX-1 and COX-2. COX-2 plays important role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system [1]. Indomethacin is a potent COX-1 and COX-2 inhibitor with IC50 value of 0.05 μM and 0.75 μM, and is also a nonsteroidal antiinflammatory drug. Indomethacin is a substituted indole acetic acid and many of the structurally diverse indomethacin esters and amides show enhanced selectivity for the COX-2 isoform. Indomethacin heptyl ester was more potent and selective COX-2 inhibitor with IC50 value of 0.04 μM and >66 μM for human recombinant COX-2 and COX-1, respectively [1].
- Properties
  - Alternative Name
    
    1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, 1-heptyl ester
    
    CAS Number
    
    282728-47-6
    
    Molecular Formula
    
    C26H30ClNO4
    
    Molecular Weight
    
    456.0
    
    Appearance
    
    A solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice.
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Indomethacin heptyl ester

Indomethacin heptyl ester

Background

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