IL-21, human recombinant protein

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Background

Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. IL-21 induces the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells, apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling and stimulates IgG production in conjunction with IL-4. Also, IL-21 enhances the anti-tumor activity of CD8+ T-cells and NK cells. The IL21/IL21 R interaction plays important roles in B and T-cell proliferation after antigen stimulation and NK cell maturation.
The human IL-21 cDNA encodes a 155 aa protein with a 22 aa signal sequence. Recombinant human IL-21 is a homodimeric, non-glycosylated polypeptide containing 133 amino acid residues and has a molecular weight of 15.5 kDa.