Apo-SAA, human recombinant protein

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Background

Serum amyloid A protein (Apo-SAA) is an acute phase response protein and injury specific apolipoprotein mainly produced by the liver. Human serum amyloid A protein (Apo-SAA) is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 µg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein.
The human apo-SAA cDNA encodes a 122 aa protein with a 18 aa N-terminal signal sequence. Recombinant human apo-SAA is a 11.5 kDa protein containing 105 amino acid residues.