IGF-II, human recombinant

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Background

Insulin-like Growth Factor-II (IGF-II) is a polypeptide endocrine hormone structurally similar to insulin and belongs to insulin-like growth factor family. IGF-II have a much higher growth-promoting activity than insulin and binds to the tyrosine kinase type I receptor (IGF-IR) and the IGF-II/Mannose-6-phosphate receptor. IGF-II expression is influenced by placenta lactogen.
Human IGF-II is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides, which are proteolyzed to produce the identical 7.5 kDa mature IGF-II. Mature IGF-II is highly conserved between the human, bovine and porcine proteins (100% identity), and exhibits cross-species activity. Recombinant Human IGF-II is a 7.5 kDa protein containing 67 amino acid residues.