IGF-1 ELISA

IGF-I is present in low concentrations in various body fluids and in conditioned cell culture media of many cell lines. However, the determination of IGF-I in these specimens is particularly difficult due to the presence of IGFBPs usually in excessive amounts. This explains why conventional assays, in which IGFBPs are not removed, result in incorrect IGF-I values, which reflect more the present amount of IGFBP rather than the exact concentration of IGF-I. The low IGF-I concentrations require often additional efforts after the extraction procedure to concentrate the extract for obtaining a satisfactory sensitivity. The IGFBP-blocked IGF-1 ELISA avoids these problems and allows the simple, correct and sensitive IGF-I determination in numerous samples at the same time.

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