IBMX

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    IBMX is a widely-used non-specific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively[1].
    By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists[2].
    Sprague–Dawley rats receive an i.c.v. injection(IBMX or saline) 10 min before receiving an i.p. injectionof cocaine or saline. Intracerebroventricular IBMX does not affect the acute hyperlocomotor responseto cocaine, but when coadministered with cocaine for 7 consecutive days, attenuated development ofbehavioral sensitization. These results suggest that IBMX inhibition of PDE-mediated adenosine production[3].
    
    [1]. Wu BN, et al. KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. Br J Pharmacol, 2004, 142(7): 1105-14.
    [2]. Snyder S H, Katims J J, Annau Z, et al. Adenosine receptors and behavioral actions of methylxanthines. Proc. Natl. Acad. Sci. USA, 1981, 78(5): 3260-3264.
    [3]. Schroeder J A, Ruta J D, Gordon J S, et al. The phosphodiesterase inhibitor isobutylmethylxanthine attenuates behavioral sensitization to cocaine. Behavioural Pharmacology, 2012, 23(3): 310-314.
- Properties
  - Alternative Name
    
    3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione
    
    CAS Number
    
    28822-58-4
    
    Molecular Formula
    
    C10H14N4O2
    
    Molecular Weight
    
    222.24
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥9.45 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Fang YX, Zou Y, et al. "lnc TINCR induced by NOD1 mediates inflammatory response in 3T3-L1 adipocytes." Gene. 2019 May 25;698:150-156. PMID:30851423

IBMX

Background

We Also Recommend

PD 146176

SecinH3