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I-BET 151 hydrochloride

I-BET 151 hydrochloride

Catalog Number:

L002371178APE

Mfr. No.:

APE-B5670

Price:

$254

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- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    I-BET 151 dihydrochloride is a bET bromodomain inhibitor that prevents BET from recruiting to chromatin. I-BET 151 induces MLL-fusion leukemia cell line apoptosis and G0 / G1 cell cycle arrest in vitro, and reduces BCL2 expression in NOMO1 cells. I-BET 151 improves the survival rate of two kinds of MLL fusion leukemia mice, and enhances the differentiation of human iPSCs into megakaryocytes.
- Properties
  - Alternative Name
    
    7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2-ol hydrochloride
    
    CAS Number
    
    1883545-47-8
    
    Molecular Formula
    
    C23H21N5O3·HCl
    
    Molecular Weight
    
    451.9
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥22.05 mg/mL in EtOH; ≥31.7 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=NOC(C)=C1C2=CC3=NC=C(N=C(O)N4[C@](C5=CC=CC=N5)([H])C)C4=C3C=C2OC.Cl
    
    * For Research Use Only
- Reference
  - 1. Ramallo IA, Alonso VL, et al. "A Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts." ACS Comb Sci.2018 Apr 9;20(4):220-228. PMID:29481050

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