Hydroxy-dPEG®₈-t-butyl ester

Hydroxy-dPEG®8-t-butyl ester, product number 10185, is a versatile building block based upon a monodispersed polyethylene glycol (PEG) chain. A primary alcohol group terminates one end of the molecule. The opposite end is a propionic acid group protected as the tert-butyl ester. The terminal hydroxy group can be functionalized with various reactive groups to permit direct modification of surfaces, small molecules, or biomolecules. The tert-butyl ester deprotects with trifluoroacetic acid (TFA), exposing the terminal propionic acid, which can then be activated as the NHS or TFP ester or directly coupled to an amine using a suitable carbodiimide.

What is different about dPEG® products?
OurdPEG® products are uniform (that is, monodispersed) polyethylene glycol (PEG) products. Unlike traditional PEGylation reagents, our dPEG® products have no dispersity. We synthesize our dPEG® reagents from highly pure building blocks. Our single molecular weight, discrete length PEG (dPEG®) products simplify the analysis of conjugates compared to dispersed PEG products because our dPEG® products contain only one PEG chain. A simplified analysis saves our customers time and money.

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