Hydroxy-dPEG®₁₂-t-butyl ester

Hydroxy-dPEG®12-t-butyl ester, product number 10719, is a monodisperse PEGylation reagent that is useful as a building block for a variety of different functional groups. The core of the molecule is a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. One end of the product terminates with a hydroxy group, while the other terminus is a propionic acid group protected as a tert-butyl ester. Many different functional groups, such as azide, amine, thiol, tosylate, or mesylate (among many others), readily modify the terminal hydroxy group. The t-butyl ester deprotects readily with trifluoroacetic acid (TFA) to expose the propionic acid group, which then can form amide bonds with amino groups.

PEGylation with monodispersed dPEG® products
Ourmonodisperse PEG reagents sold under the dPEG® trade name are single molecular weight PEGylation reagents with discrete chain lengths. Unlike disperse PEGylation reagents that contain a variety of PEG chain lengths and molecular weights, our dPEG® products have no dispersity. Consequently, the analysis of conjugates made with our products is far simpler and less time consuming than conjugates prepared with PEG products that have dispersity.

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