Human Tumor Necrosis Factor Alpha ELISA Kit (TNFa)

Tumor Necrosis Factor; Cachectin; Tnf-Alpha; Tumor Necrosis Factor Ligand Superfamily Member 2; Tnf-A Cleaved Into - Tumor Necrosis Factor - Membrane Form; N-Terminal Fragment; Ntf - Intracellular Domain 1; Icd1 - Intracellular Domain 2; Icd2 - C-Domain 1 - C-Domain 2 - Tumor Necrosis Factor - Soluble Form

Uniprot ID: OLR1_HUMAN ; Reactome: R-HSA-381340 ; Gene ID: 7124 ; Gene Symbol: TNF

Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.