Human TNKS2 (Tankyrase 2) CLIA Kit

Poly Adp-Ribose Polymerase Tankyrase-2; Adp-Ribosyltransferase Diphtheria Toxin-Like 6; Artd6; Poly Adp-Ribose Polymerase 5b; Protein Poly-Adp-Ribosyltransferase Tankyrase-2; Tnks-2; Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2; Tankyrase Ii; Tankyrase-2; Tank2; Tankyrase-Like Protein; Tankyrase-Related Protein

TNKS2_HUMAN ; Reactome: R-HSA-201681 ; Gene ID: 80351

Tissue Specificity: Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.

Function: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.