Human TNFSF14 (Tumor Necrosis Factor Ligand Superfamily, Member 14) CLIA Kit

Tumor Necrosis Factor Ligand Superfamily Member 14; Herpes Virus Entry Mediator Ligand; Hvem-L; Herpesvirus Entry Mediator Ligand; Cd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form

TNF14_HUMAN ; Reactome: R-HSA-5668541 ; Gene ID: 8740

Tissue Specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production.