Human TDGF1 (Teratocarcinoma Derived Growth Factor 1) CLIA Kit

Teratocarcinoma-Derived Growth Factor 1; Cripto-1 Growth Factor; Crgf; Epidermal Growth Factor-Like Cripto Protein Cr1

TDGF1_HUMAN ; Reactome: R-HSA-1181150 ; Gene ID: 6997

Tissue Specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Function: GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.