Name: Human sRank Ligand Recombinant Protein (Animal Free) Lyophilized
Price: 613.00 USD

- Overview
  - Human sRank Ligand Recombinant Protein (Animal Free) Lyophilized from Innovative Research has been recombinantly produced in E. coli. This is a Lyophilized protein buffered in with a purity of ? 98% by SDS-PAGE gel and HPLC analyses.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Human RANKL is reactive on murine cells. Recombinant Human sRANKL is a 20.0 kDa polypeptide comprising the TNF-homologous region of RANKL (176 amino acid residues).
- Properties
  - Protein Name
    
    TNFSF11
    
    Source
    
    E. coli
    
    Type
    
    Animal Free Proteins
    
    Purification
    
    >98% by SDS-PAGE gel and HPLC analyses.
    
    Storage
    
    The recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
    
    * These products are supplied for manufacturing, research and laboratory use only.

Human sRank Ligand Recombinant Protein (Animal Free) Lyophilized

Human sRank Ligand Recombinant Protein (Animal Free) Lyophilized

Background

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