Human SEMA7A (Semaphorin 7A) CLIA Kit

Semaphorin-7a; Cdw108; Jmh Blood Group Antigen; John-Milton-Hargen Human Blood Group Ag; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; Cd Antigen Cd108

SEM7A_HUMAN ; Reactome: R-HSA-416700 ; Gene ID: 8482

Tissue Specificity: Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.

Function: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.