Human SELP (P-Selectin) CLIA Kit

P-Selectin; Cd62 Antigen-Like Family Member P; Granule Membrane Protein 140; Gmp-140; Leukocyte-Endothelial Cell Adhesion Molecule 3; Lecam3; Platelet Activation Dependent Granule-External Membrane Protein; Padgem; Cd Antigen Cd62p

LYAM3_HUMAN ; Reactome: R-HSA-114608 ; Gene ID: 6403

Tissue Specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.