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Human SCAP full length protein-synthetic nanodisc

Human SCAP full length protein-synthetic nanodisc

Catalog Number:

P001561641DIM

Mfr. No.:

FLP100498

Price:

$1,013

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Quantity:

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- Overview
  - Target: SCAP
    Tag: C-Flag Tag
    Protein Families: Druggable Genome, Transcription Factors, Transmembrane
    
    Please contact us at for specific academic pricing.
    
    Background
    
    A protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.
- Properties
  - Type
    
    Synthetic Nanodiscs
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
    
    Storage
    
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    
    Molecular Weight
    
    The human full length SCAP protein has a MW of 139.7 kDa
    
    Expression system
    
    HEK293
    
    More Information
    
    UniProt
    
    Q12770
    
    * For research use only.

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