Human PRF1 (Perforin 1/Pore-Forming Protein) CLIA Kit

Perforin-1; P1; Cytolysin; Lymphocyte Pore-Forming Protein; Pfp

PERF_HUMAN ; Gene ID: 5551

Function: Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.