Name: Human Myostatin
Price: Inquiry

- Overview
  - Predicted MW: Dimer, 12.4/24.8 kDa (109/218 aa). Myostatin, also known as GDF-8, is a conserved member of the TGF-beta superfamily. Myostatin is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA or ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.
    
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- Properties
  - Protein Name
    
    Growth/differentiation factor 8, Myostatin
    
    Source
    
    Genetically modified E.coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Reducing and Non-Reducing SDS PAGE at >= 95%
    
    Formulation
    
    Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
    Sterile 20 mM HCl at 0.1 mg/mL
    
    Storage
    
    Store at -20°C
    
    Endotoxin
    
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
    
    More Information
    
    UniProt
    
    O14793(267-375)
    
    Gene ID
    
    2660
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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