Human MUC1 (Mucin 1) ELISA Kit

Mucin-1; Muc-1; Breast Carcinoma-Associated Antigen Df3; Cancer Antigen 15-3; Ca 15-3; Carcinoma-Associated Mucin; Episialin; H23ag; Krebs Von Den Lungen-6; Kl-6; Pemt; Peanut-Reactive Urinary Mucin; Pum; Polymorphic Epithelial Mucin; Pem; Tumor-Associated Epithelial Membrane Antigen; Ema; Tumor-Associated Mucin; Cd Antigen Cd227 Cleaved Into - Mucin-1 Subunit Alpha; Muc1-Nt; Muc1-Alpha - Mucin-1 Subunit Beta; Muc1-Beta; Muc1-Ct

MUC1_HUMAN ; Reactome: R-HSA-5083625 ; Gene ID: 4582

Tissue Specificity: Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only.

Function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.