Human MASP1 (Mannan Associated Serine Protease 1) CLIA Kit

Mannan-Binding Lectin Serine Protease 1; Complement Factor Masp-3; Complement-Activating Component Of Ra-Reactive Factor; Mannose-Binding Lectin-Associated Serine Protease 1; Masp-1; Mannose-Binding Protein-Associated Serine Protease; Ra-Reactive Factor Serine Protease P100; Rarf; Serine Protease 5 Cleaved Into - Mannan-Binding Lectin Serine Protease 1 Heavy Chain - Mannan-Binding Lectin Serine Protease 1 Light Chain

MASP1_HUMAN ; Reactome: R-HSA-166662 ; Gene ID: 5648

Tissue Specificity: Protein of the plasma which is primarily expressed by liver.

Function: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.