Human LRP6 (Low Density Lipoprotein Receptor Related Protein) CLIA Kit

Low-Density Lipoprotein Receptor-Related Protein 6; Lrp-6

LRP6_HUMAN ; Reactome: R-HSA-201681 ; Gene ID: 4040

Tissue Specificity: Widely coexpressed with LRP5 during embryogenesis and in adult tissues.

Function: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.