Human LILRB4 (Leukocyte Immunoglobulin Like Receptor Subfamily B Member 4) CLIA Kit

Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4; Cd85 Antigen-Like Family Member K; Immunoglobulin-Like Transcript 3; Ilt-3; Leukocyte Immunoglobulin-Like Receptor 5; Lir-5; Monocyte Inhibitory Receptor Hm18; Cd Antigen Cd85k

LIRB4_HUMAN ; Reactome: R-HSA-198933 ; Gene ID: 11006

Tissue Specificity: Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.

Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.