Human Leukocyte surface antigen CD44 ELISA Kit（CD44）

Cd44 Antigen; Cdw44; Epican; Extracellular Matrix Receptor Iii; Ecmr-Iii; Gp90 Lymphocyte Homing/Adhesion Receptor; Hutch-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate Receptor; Phagocytic Glycoprotein 1; Pgp-1; Phagocytic Glycoprotein I; Pgp-I; Cd Antigen Cd44

CD44_HUMAN ; Reactome: R-HSA-1474228 ; Gene ID: 960 ; Gene Symbol: CD44

Function: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.