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Overview
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Target Information
Target NameTyrosine-Protein Kinase Jak1; Janus Kinase 1; Jak-1Database LinksJAK1_HUMAN ; Reactome: R-HSA-1059683 ; Gene ID: 3716About TargetTissue Specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor.
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Overview