Name: Human Fibroblast Growth Factor-7 (AF)
Price: Inquiry

- Overview
  - Predicted MW: Monomer, 19 kDa (164 aa). Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), is a potent mitogen that regulates epithelial cell migration and differentiation. FGF-7 is produced by mesenchymal cells and binds in high affinity to a splice variant of FGF receptor 2 (FGFR2-IIIb). The mitogenic activity of FGF-7 acts predominantly on keratinocytes, but not on fibroblast or endothelial cells. FGF-7 expression is upregulated after acute and chronic injury, suggesting that FGF-7 functions during the healing of injured epithelial cells. FGF-7 also induces the formation of the apical ectodermal ridge during limb development.
    
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- Properties
  - Protein Name
    
    KGF, Heparin-binding growth factor 7, Keratinocyte growth factor
    
    Source
    
    Genetically modified E.coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Reducing and Non-Reducing SDS PAGE at >= 90%
    
    Formulation
    
    Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 100 mM sodium chloride, pH 7.5
    Sterile water at 0.1 mg/mL
    
    Storage
    
    Store at -20°C
    
    Endotoxin
    
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
    
    Activity
    
    Biological Activity was determined by 4MBr-5 cell proliferation at <=60 ng/mL; >= 1.7 x 10^4 units/mg (typical ED50 is < 5 ng/mL). Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.
    
    More Information
    
    UniProt
    
    P21781
    
    Gene ID
    
    2252
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human Fibroblast Growth Factor-7 (AF)

Human Fibroblast Growth Factor-7 (AF)

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